Malignant Paraganglioma Arising from the Posterior Mediastinum : A Case Report and Review of the Literature

Isobe Takeshi

Oguri Tetsuya

Yamasaki Masahiro

Daga Haruko

Ishikawa Hisanobu

Fujitaka Kazunori

Ochiai Mari

Kitaguchi Souichi

Ishioka Shinichi

Yamakido Michio

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

An unusual case of paraganglioma of posterior mediastinum occurred in a young adult with local recurrence and multiple distant metastasis. Because of its rarity, the determinants of prognosis factor between benign and malignant paraganglioma are uncertain. In this case, we investigated abnormalities of the p53 gene and ras gene mutations in tissues of primary and metastatic lesions. Neither abnormalities of p53 gene nor ras gene mutations were detected. The molecular approach is recommended as a means of clarifying the trend towards the malignancy of paraganglioma.

Malignant paraganglioma

Posterior mediastinum

p53

ras

医学 [ 490 ]

英語

Hiroshima University Medical Press

[ISSN] 0018-2052

[NCID] AA00664312