The Influence of Lung Function on Exercise Capacity in Patients with Type 2 Diabetes

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Title ( eng )
The Influence of Lung Function on Exercise Capacity in Patients with Type 2 Diabetes
Creator
Kitahara Yoshihiro
Hattori Noboru
Yokoyama Akihito
Inamizu Tsutomu
Source Title
Hiroshima Journal of Medical Sciences
Volume 59
Issue 1
Start Page 7
End Page 13
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Patients with type 2 diabetes have impaired exercise capacity. While numerous factors are known to contribute to impaired exercise capacity, the role of lung function remains unclear. We conducted the present study to investigate the influence of lung function on exercise capacity in patients with type 2 diabetes.

Cardiopulmonary exercise testing was carried out in 31 male patients with type 2 diabetes without diabetic complications or cardiopulmonary diseases. Patients with abnormal spirometry results such as a percentage of predicted forced vital capacity (%FVC) < 80% and/or a ratio of forced expiratory volume in one second (FEV1) to FVC (FEV1/FVC) < 70% were excluded from the study. We used the percentage of predicted maximal oxygen uptake (%V02max) as an index of exercise capacity. The correlations between %V02max and lung function and other factors known to be associated with impaired exercise capacity were then assessed.

Univariate analysis revealed % V02max correlated significantly with percentage of predicted FEV1 (%FEV1), duration of type 2 diabetes, regular exercise habits, and systolic and diastolic blood pressures. In a multivariate analysis, %FEV 1 and regular exercise habits were found to be independent determinants of% V02max.

A mild reduction in %FEV 1, which may be a complication of diabetes, is associated with impaired exercise capacity in patients with type 2 diabetes. When evaluating spirometric values in patients with type 2 diabetes, a reduction in %FEV1 should be noted even when both %FVC and FEV 1/FVC are within normal limits.
Keywords
Exercise capacity
Lung function
%FEV1
Type 2 diabetes
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2010-03
Rights
(c) Hiroshima University Medical Press.
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312