A Water-soluble Extract from Culture Medium of Ganoderma lucidum Mycelia Suppresses the Development of Colorectal Adenomas

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Title ( eng )
A Water-soluble Extract from Culture Medium of Ganoderma lucidum Mycelia Suppresses the Development of Colorectal Adenomas
Creator
Oka Shiro
Ito Masanori
Source Title
Hiroshima Journal of Medical Sciences
Volume 59
Issue 1
Start Page 1
End Page 6
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
A water-soluble extract from a cultured medium of Ganoderma lucidum mycelia (MAK) is one of the G. lucidum extracts that has been reported to show have exhibit cancer-preventive effects in the animal studies. To confirm cancer-preventive effects of MAK, we performed a no-treatment concurrent controlled trial on patients with colorectal adenomas. Patients who were determined to be carrying colorectal adenomas by colonoscopy were enrolled in this study. Patients in the MAK group took MAK (1.5 g/day) for 12 months. Follow-up colonoscopy was performed after 12 months, and the colonoscopists recorded the size, site and macroscopic type of all adenomas. Among 123 patients who enrolled in the MAK group, 96 eligible patients completed the trial. The 102 eligible patients in the no-treatment control group were selected randomly from our department's patients. The changes in the number of adenomas up to 12 months increased to 0.66 ± 0.10 (mean± SE) in the control group, while decreasing in the MAK group to -0.42 ± 0.10 (p<0.01). The total size of adenomas increased to 1.73 ± 0.28 mm in the control group and decreased to -1.40 ± 0.64 mm in the MAK group (p<0.01). The results suggest that MAK suppresses the development of colorectal adenomas - precancerous lesions of the large bowel.
Keywords
Ganoderma lucidum
Colorectal adenoma
Cancer prevention
Clinical trial
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2010-03
Rights
(c) Hiroshima University Medical Press.
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312