Real time assessment of surface interactions with a titanium passivation layer by surface plasmon resonance

Acta Biomaterialia 8 巻 3 号 1260-1266 頁 2012 発行
アクセス数 : 905
ダウンロード数 : 274

今月のアクセス数 : 1
今月のダウンロード数 : 1
ファイル情報(添付)
ActBiomat_8_1260.pdf 717 KB 種類 : 全文
タイトル ( eng )
Real time assessment of surface interactions with a titanium passivation layer by surface plasmon resonance
作成者
Yoshida Yasuhiro
Nagaoka Noriyuki
Maekawa Kenji
Kuboki Takuo
Akagawa Yasumasa
Suzuki Kazuomi
Meerbeek Bart Van
Messersmith Phillip B.
収録物名
Acta Biomaterialia
8
3
開始ページ 1260
終了ページ 1266
抄録
Due to the high corrosion resistance and strength to density ratio titanium is widely used in industry, and also in a gamut of medical applications. Here we report for the first time on our development of a titanium passivation layer sensor that makes use of surface plasmon resonance (SPR). The deposited titanium metal layer on the sensor was passivated in air, similarly to titanium medical devices. Our "Ti-SPR sensor" enables analysis of biomolecule interactions with the passivated surface of titanium in real time. As a proof of concept, corrosion of a titanium passivation layer exposed to acid was monitored in real time. The Ti-SPR sensor can also accurately measure the time-dependence of protein adsorption onto the titanium passivation layer at sub-nanogram per square millimeter accuracy. Besides such SPR analyses, SPR imaging (SPRI) enables real time assessment of chemical surface processes that occur simultaneously at "multiple independent spots" on the Ti-SPR sensor, such as acid corrosion or adhesion of cells. Our Ti-SPR sensor will therefore be very useful to study titanium corrosion phenomena and biomolecular titanium-surface interactions with application in a broad range of industrial and biomedical fields.
著者キーワード
Titanium passivation layer
Surface plasmon resonance
Protein adsorption
Cell adhesion
Biosensor
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier Science Ltd
発行日 2012
権利情報
(c) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 1742-7061
[DOI] 10.1016/j.actbio.2011.11.025
[NCID] AA11976339
[DOI] http://dx.doi.org/10.1016/j.actbio.2011.11.025