Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring

Hormones and Behavior 56 巻 1 号 112-120 頁 2009 発行
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タイトル ( eng )
Maternal postpartum learned helplessness (LH) affects maternal care by dams and responses to the LH test in adolescent offspring
作成者
Kurata Akiko
Morinobu Shigeru
Yamamoto Shigeto
収録物名
Hormones and Behavior
56
1
開始ページ 112
終了ページ 120
抄録
It is known that the early environment affects the mental development of rodent and human offspring. However, it is not known specifically whether a postpartum depressive state influences the depressive state in offspring. Using learned helplessness (LH) in rats as an animal model of depression, we examined the influence of maternal postpartum LH on responses to the LH test of offspring. Dam rats were judged as LH or non-helpless (nLH) on postnatal days (PN) 2-3, and maternal behavior was recorded during PN2-14. On PN 45-46, offspring were subjected to the LH test. Plasma corticosterone (CORT) levels, hippocampal levels of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) mRNA were measured before and after the LH test in offspring. Active nursing in LH dams was significantly lower than that in nLH dams. Susceptibility to LH in the offspring of LH dams was significantly higher than in those of nLH dams, and was negatively correlated with active nursing by LH dams. The GR mRNA levels before and after the LH test were lower in the offspring of LH dams than in those of nLH dams, and the reduced basal GR mRNA and protein might have resulted in the higher CORT response after the LH test. There was no significant difference in BDNF mRNA in the offspring of LH and nLH dams. These findings suggest that early postpartum LH decreased active nursing and increased depression-like behavior in the adolescent offspring via dysfunction of the hypothalamic-pituitary-ad renal axis.
著者キーワード
Learned helplessness
Early postpartum period
Maternal behavior
Hypothalamic-pituitary-adrenal (HPA) axis
Glucocorticoid receptor
Corticosterone
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Academic Press Inc
Elsevier Science
発行日 2009
権利情報
Copyright (c) 2009 Elsevier Inc.
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-506X
[DOI] 10.1016/j.yhbeh.2009.03.016
[NCID] AA00665370
[DOI] http://dx.doi.org/10.1016/j.yhbeh.2009.03.016