The impact of visceral adipose tissue and high-molecular weight adiponectin on cardio-ankle vascular index in asymptomatic Japanese subjects
Metabolism-Clinical and Experimental 58 巻 7 号
1023-1029 頁
2009 発行
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タイトル ( eng ) |
The impact of visceral adipose tissue and high-molecular weight adiponectin on cardio-ankle vascular index in asymptomatic Japanese subjects
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作成者 |
Ohashi Norihiko
Ito Chikako
Fujikawa Rumi
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収録物名 |
Metabolism-Clinical and Experimental
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巻 | 58 |
号 | 7 |
開始ページ | 1023 |
終了ページ | 1029 |
抄録 |
Few studies addressed the relation of visceral adiposity and high-molecular weight (HMW) adiponectin to arterial stiffness. We investigated the impact of visceral adipose tissue (VAT) and HMW adiponectin on cardio-ankle vascular index (CAVI) in asymptomatic Japanese subjects. We studied 487 consecutive subjects (271 men and 216 women) who underwent general health examination between October 2005 and May 2008. The abdominal, visceral, and subcutaneous adipose tissue areas were determined by low-dose x-ray computed tomography. Serum levels of total and HMW adiponectin were measured using the enzyme-linked immunosorbent assay system based on a monoclonal antibody to humans. Cardio-ankle vascular index was positively correlated with VAT area and negatively correlated with HMW adiponectin levels. We also found the positive association of the number of metabolic syndrome components with CAVI in both sexes. A stepwise multiple regression analysis revealed that age, VAT area, serum HMW adiponectin levels, and homeostasis model assessment of insulin resistance were independent determinants of CAVI. Receiver operating characteristic analyses demonstrated that the predictive value of the VAT area for the extent of CAVI (mild: <25th percentile vs severe: >75th percentile) exceeded that of total or HMW adiponectin levels in both sexes. In conclusion, increased CAVI is associated with both amounts of VAT measured by computed tomography and serum HMW adiponectin levels in asymptomatic Japanese subjects. Receiver operating characteristic analysis indicates that the VAT area is a lot better predictor of arterial stiffness than adiponectin levels.
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著者キーワード |
visceral adipose tissue (VAT)
high-molecular weight (HMW) adiponectin
metabolic syndrome (MetS)
cardio-ankle vascular index (CAVI)
arterial stiffness
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NDC分類 |
医学 [ 490 ]
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
W B Saunders CO-Eleevier Inc
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発行日 | 2009 |
権利情報 |
Copyright (c) 2009 Elsevier Inc.
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出版タイプ | Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版) |
アクセス権 | オープンアクセス |
収録物識別子 |
[ISSN] 0026-0495
[DOI] 10.1016/j.metabol.2009.03.005
[NCID] AA0073583X
[DOI] http://dx.doi.org/10.1016/j.metabol.2009.03.005
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