A new animal model for Ménière's disease

Takumida Masaya

Akagi Nana

Anniko Matti

Acta Oto-Laryngologica

Conclusion. A new mouse model for Ménière's disease has been developed by the treatment with both LPS and aldosterone. The induction of vestibular dysfunction in the hydropic animals model may require additional stress such as reduced inner ear blood flow, acute changes of endolymph volume and/or pressure, etc. Objective. The aim of this study is to develop a more suitable animal model, which shows more resemblance to the pathophysiological process in Ménière's disease. Materials and methods. Adult CBA/J mice were treated with intratympanic injection of LPS, intraperitoneal injection of aldosterone or injection of both LPS and aldosterone. Morphological analysis was performed in the cochlea and endolymphatic sac. Results. All experimental animals showed mild to moderate endolymphatic hydrops. The animals treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.

endolymphatic hydrops

lipopolysaccharide

aldosterone

mice

Ménière's disease

医学 [ 490 ]

英語

Taylor & Francis

Copyright (c) 2008 Taylor & Francis

[ISSN] 0001-6489

[DOI] 10.1080/00016480701497436

[NCID] AA0050923X

[DOI] http://dx.doi.org/10.1080/00016480701497436