A new animal model for Ménière's disease
Acta Oto-Laryngologica Volume 128 Issue 3
Page 263-271
published_at 2008
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| File | |
| Title ( eng ) |
A new animal model for Ménière's disease
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| Creator |
Akagi Nana
Anniko Matti
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| Source Title |
Acta Oto-Laryngologica
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| Volume | 128 |
| Issue | 3 |
| Start Page | 263 |
| End Page | 271 |
| Abstract |
Conclusion. A new mouse model for Ménière's disease has been developed by the treatment with both LPS and aldosterone. The induction of vestibular dysfunction in the hydropic animals model may require additional stress such as reduced inner ear blood flow, acute changes of endolymph volume and/or pressure, etc. Objective. The aim of this study is to develop a more suitable animal model, which shows more resemblance to the pathophysiological process in Ménière's disease. Materials and methods. Adult CBA/J mice were treated with intratympanic injection of LPS, intraperitoneal injection of aldosterone or injection of both LPS and aldosterone. Morphological analysis was performed in the cochlea and endolymphatic sac. Results. All experimental animals showed mild to moderate endolymphatic hydrops. The animals treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.
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| Keywords |
endolymphatic hydrops
lipopolysaccharide
aldosterone
mice
Ménière's disease
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Taylor & Francis
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| Date of Issued | 2008 |
| Rights |
Copyright (c) 2008 Taylor & Francis
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0001-6489
[DOI] 10.1080/00016480701497436
[NCID] AA0050923X
[DOI] http://dx.doi.org/10.1080/00016480701497436
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