Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts
Experimental Lung Research 34 巻 7 号
373-390 頁
2008-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Exploration of the genes responsible for unlimited proliferation of immortalized lung fibroblasts
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| 作成者 |
Tanimoto Keiji
Nishimura Youhei
Tsugane Momomi
Fukuba Ikuko
Nishiyama Masahiko
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| 収録物名 |
Experimental Lung Research
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| 巻 | 34 |
| 号 | 7 |
| 開始ページ | 373 |
| 終了ページ | 390 |
| 抄録 |
Regulation mechanism of lung fibroblast proliferation remains unknown. To elucidate the key molecules in it, we here established mortal and immortal non-transformed lung fibroblast cell line/strains with elongated lifespan by telomerase reversetranscriptase gene transfection. Comparing the expression profiles of them, 51 genes were explored to be the candidates responsible for regulation of cellular proliferation of lung fibroblasts. This set of fibrobrast strains of same origin with different proliferative capacities may become useful model cells for research on lung fibroblast growth regulation and the candidate genes explored in this study may provide biomarkers or therapeutic targets of pulmonary fibrosis.
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| 著者キーワード |
lung fibroblast
microarray
growth regulation
proliferation
telomerase
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Taylor & Francis Inc
|
| 発行日 | 2008-09 |
| 権利情報 |
Copyright (c) 2008 Taylor & Francis
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
This is a preprint of an article submitted for consideration in the Experimental Lung Research © 2008 copyright Taylor & Francis; Experimental Lung Research is available online at informaworldTM with the open URL of your article;
[ISSN] 0190-2148
[DOI] 10.1080/01902140802221912
[NCID] AA00181680
[DOI] http://dx.doi.org/10.1080/01902140802221912
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