Central insulin suppresses feeding behavior via melanocortins in chicks

Domestic Animal Endocrinology 34 巻 3 号 227-229 頁 2008-04 発行
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タイトル ( eng )
Central insulin suppresses feeding behavior via melanocortins in chicks
作成者
Shiraishi Jun-ichi
Yanagita Kouichi
Fujita Masanori
収録物名
Domestic Animal Endocrinology
34
3
開始ページ 227
終了ページ 229
抄録
Growing evidence suggests that insulin interacts with both orexigenic and anorexigenic peptides in the brain for the control of feeding behavior in mammals. However, the action of central insulin in chicks has not yet been identified. In the present study, we investigated the effects of central injection of insulin on feeding behavior in chicks. Intracerebroventricular (ICV) administration of insulin, at doses that do not influence peripheral glucose levels, significantly inhibited food intake in chicks. Central injection of insulin in chicks significantly increased expression of pro-opiomelanocortin (POMC) mRNA, and decreased that of neuropeptide Y (NPY) mRNA. Finally, co-injection of the melanocortin antagonist (SHU9119 or HS014) prevented the reduction in food intake caused by ICV administration of insulin. These data suggest that insulin functions in chicks as an appetite-suppressive peptide in the central nervous system, and that the central melanocortin system mediates this anorexic effect of insulin, as in mammals.
著者キーワード
POMC
food intake
insulin
central nervous system
chick
melanocortins
NDC分類
動物学 [ 480 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier Inc
発行日 2008-04
権利情報
Copyright (c) 2007 Elsevier Inc
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0739-7240
[NCID] AA10632527
[DOI] 10.1016/j.domaniend.2007.05.002
[DOI] http://dx.doi.org/10.1016/j.domaniend.2007.05.002 ~の異版である