Central insulin suppresses feeding behavior via melanocortins in chicks

Domestic Animal Endocrinology Volume 34 Issue 3 Page 227-229 published_at 2008-04
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Title ( eng )
Central insulin suppresses feeding behavior via melanocortins in chicks
Creator
Shiraishi Jun-ichi
Yanagita Kouichi
Fujita Masanori
Source Title
Domestic Animal Endocrinology
Volume 34
Issue 3
Start Page 227
End Page 229
Abstract
Growing evidence suggests that insulin interacts with both orexigenic and anorexigenic peptides in the brain for the control of feeding behavior in mammals. However, the action of central insulin in chicks has not yet been identified. In the present study, we investigated the effects of central injection of insulin on feeding behavior in chicks. Intracerebroventricular (ICV) administration of insulin, at doses that do not influence peripheral glucose levels, significantly inhibited food intake in chicks. Central injection of insulin in chicks significantly increased expression of pro-opiomelanocortin (POMC) mRNA, and decreased that of neuropeptide Y (NPY) mRNA. Finally, co-injection of the melanocortin antagonist (SHU9119 or HS014) prevented the reduction in food intake caused by ICV administration of insulin. These data suggest that insulin functions in chicks as an appetite-suppressive peptide in the central nervous system, and that the central melanocortin system mediates this anorexic effect of insulin, as in mammals.
Keywords
POMC
food intake
insulin
central nervous system
chick
melanocortins
NDC
Zoology [ 480 ]
Language
eng
Resource Type journal article
Publisher
Elsevier Inc
Date of Issued 2008-04
Rights
Copyright (c) 2007 Elsevier Inc
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 0739-7240
[NCID] AA10632527
[DOI] 10.1016/j.domaniend.2007.05.002
[DOI] http://dx.doi.org/10.1016/j.domaniend.2007.05.002 isVersionOf