Effects of N-terminal fragments of β-endorphin on feeding in chicks

Neuroscience Letters 442 巻 2 号 140-142 頁 2008-09 発行
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タイトル ( eng )
Effects of N-terminal fragments of β-endorphin on feeding in chicks
作成者
Yanagita Kouichi
Shiraishi Jun-ichi
Fujita Masanori
収録物名
Neuroscience Letters
442
2
開始ページ 140
終了ページ 142
抄録
It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
著者キーワード
β-Endorphin
N-terminal fragment
feeding behavior
central nervous system
chick
NDC分類
動物学 [ 480 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Elsevier Ireland Ltd
発行日 2008-09
権利情報
Copyright (c) 2008 Elsevier Ireland Ltd
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0304-3940
[NCID] AA00754925
[DOI] 10.1016/j.neulet.2008.07.018
[PMID] 18638524
[DOI] http://dx.doi.org/10.1016/j.neulet.2008.07.018 ~の異版である