Effects of N-terminal fragments of β-endorphin on feeding in chicks
Neuroscience Letters Volume 442 Issue 2
Page 140-142
published_at 2008-09
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| File | |
| Title ( eng ) |
Effects of N-terminal fragments of β-endorphin on feeding in chicks
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| Creator |
Yanagita Kouichi
Shiraishi Jun-ichi
Fujita Masanori
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| Source Title |
Neuroscience Letters
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| Volume | 442 |
| Issue | 2 |
| Start Page | 140 |
| End Page | 142 |
| Abstract |
It is known that N-terminal fragments of β-endorphin have biological activities, such as an antagonism effect of β-endorphin (1–31) on the secretion of hormones or thermoregulation in mammals. We studied the effects of the N-terminal fragments on feeding behavior in male broiler chicks. Intracerebroventricular administration of β-endorphin (1–27) (0.4 nmol) stimulated feeding behavior compared with saline control during the 60-min experimental period. β-Endorphin (1–17) (2.0 nmol) also increased food intake at 30 min postinjection. Co-injection of either β-endorphin (1–27) or (1–17) was effective in reducing full-length β-endorphin-induced feeding in chicks. These data suggest that the N-terminal fragments of β-endorphin act as a partial agonist, and may regulate the activity of the central opioidergic system in chicks.
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| Keywords |
β-Endorphin
N-terminal fragment
feeding behavior
central nervous system
chick
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| NDC |
Zoology [ 480 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Elsevier Ireland Ltd
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| Date of Issued | 2008-09 |
| Rights |
Copyright (c) 2008 Elsevier Ireland Ltd
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| Publish Type | Author’s Original |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0304-3940
[NCID] AA00754925
[DOI] 10.1016/j.neulet.2008.07.018
[PMID] 18638524
[DOI] http://dx.doi.org/10.1016/j.neulet.2008.07.018
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