Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori

Journal of Gastroenterology and Hepatology 22 巻 4 号 571-576 頁 2007-04 発行
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タイトル ( eng )
Host factors contributing to the discovery of gastric cancer after successful eradication therapy of Helicobacter pylori
作成者
Takata Shunsuke
Ito Masanori
Imagawa Shinobu
Haruma Ken
収録物名
Journal of Gastroenterology and Hepatology
22
4
開始ページ 571
終了ページ 576
抄録
Background and Aim: Clinical features of patients who develop gastric cancer after successful eradication of Helicobacter pylori are still unclear. We attempted to identify host factors associated with the discovery of gastric cancer, including changes in the background gastric mucosa in patients with atrophic gastritis.

Methods: We enrolled 101 patients (59 men, 42 women; mean age 56.0 years) who underwent successful eradication therapy. All patients had no neoplastic lesion in the stomach and were diagnosed with corpus atrophic gastritis histologically before the eradication therapy. After successful eradication, these patients were followed up by an annual endoscopic examination (mean follow-up time 63.2 months; range 12–157 months). Fasting sera were obtained before and after eradication therapy and the serum levels of gastrin/pepsinogens were evaluated.

Results: Gastric cancer occurred during follow-up in eight of the 101 patients (7.9%). We compared the host features between the cancer-discovered group (n = 8) and the non-discovered group (n = 93). We found no difference in gender, history of previous treatment of gastric cancer, and serum pepsinogen/gastrin levels at entry between them. The trends in alterations of serum markers did not differ between the two groups. However, gastric cancer was more frequently found in older patients (>54 years at eradication) than in others (P < 0.05).

Conclusion: Improvement of gastric inflammation did not correlate with the discovery of gastric cancer after eradication; however, age at the time of eradication seemed to be important. Strict follow-up after eradication is needed in older patients with atrophic gastritis.
著者キーワード
eradication
gastric cancer
gastrin
Helicobacter pylori
pepsinogen
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Blackwell
発行日 2007-04
権利情報
Copyright (c) 2006 Authors ; Journal compilation (c) 2007 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[NCID] AA10727383
[ISSN] 0815-9319
[DOI] 10.1111/j.1440-1746.2006.04776.x
[DOI] http://dx.doi.org/10.1111/j.1440-1746.2006.04776.x ~の異版である