Inhibition by Long-term Fermented Miso of Induction of Pulmonary Adenocarcinoma by Diisopropanolnitrosamine in Wistar Rats
Hiroshima Journal of Medical Sciences 52 巻 1 号
9-13 頁
2003-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Inhibition by Long-term Fermented Miso of Induction of Pulmonary Adenocarcinoma by Diisopropanolnitrosamine in Wistar Rats
|
| 作成者 |
Shiraki Katsuhisa
Yano Raita
Otani Satoko
Mimeoka Akane
Watanabe Hiromitsu
|
| 寄与者 | 国立情報学研究所 |
| 収録物名 |
Hiroshima Journal of Medical Sciences
|
| 巻 | 52 |
| 号 | 1 |
| 開始ページ | 9 |
| 終了ページ | 13 |
| 収録物識別子 |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| 抄録 |
The present study was designed to investigate the effects of fermented miso in the diet on the development of lung tumors initiated by diisopropanolnitrosamine (BHP) in male Slc:Wistar rats. A total of 63 animals, 6 weeks of age, were divided into 4 groups and given BHP (2000 ppm) in their drinking water for 10 weeks. After the carcinogen treatment the rats were fed a normal control MF solid diet, or the same diet containing 100ng-term or short-term fermented miso for 12 weeks. The long-term fermented miso significantly reduced the number of lung tumors, adenocarcinomas and PCNA strongly positive tumors as compared with the short-term fermented miso. The present results thus indicate that dietary supplementation with long-term fermented miso could exert chemopreventive effects on lung carcinogenesis.
|
| 著者キーワード |
Lung tumor inhibition
BHP
Long-term fermented miso
Wistar rats
|
| NDC分類 |
医学 [ 490 ]
|
| 言語 |
英語
|
| 資源タイプ | 紀要論文 |
| 出版者 |
Hiroshima University Medical Press
|
| 発行日 | 2003-03 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 日付 |
[作成日] 2006-03-21
|
| 収録物識別子 |
[ISSN] 0018-2052
[NCID] AA00664312
|
