Genetic alterations of Wnt signal components in cancer cells
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
101-106 頁
2006-01-08 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Genetic alterations of Wnt signal components in cancer cells
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| 作成者 |
Kikuchi Akira
Kinshasa S.
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| 収録物名 |
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
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| 開始ページ | 101 |
| 終了ページ | 106 |
| 抄録 |
The genetics of development and cancer have converged in the identification of intra- and extra-cellular signaling pathways that are aberrantly regulated in cancer and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β-catenin, APC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the accumulation of cytosolic and nuclear β-catenin and the activation of transcriptional factor Tcf/Lef. The resulting gene expression profile should provide a significant clue as to cancers carrying defects in the Wnt signaling pathway. In this review, the regulation of the β-catenin stability by Axin and APC, and their genetic alterations in human cancers are described.
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| 著者キーワード |
Wnt
β-catenin
APC
Axin
Tcf
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 会議発表論文 |
| 発行日 | 2006-01-08 |
| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[URI] http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842
～の一部分である
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