Genetic alterations of Wnt signal components in cancer cells
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
Page 101-106
published_at 2006-01-08
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| File | |
| Title ( eng ) |
Genetic alterations of Wnt signal components in cancer cells
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| Creator |
Kikuchi Akira
Kinshasa S.
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| Source Title |
Hiroshima Conference on Education and Science in Dentistry, 2006 : the 40th Anniversary of Hiroshima University Faculty of Dentistry
|
| Start Page | 101 |
| End Page | 106 |
| Abstract |
The genetics of development and cancer have converged in the identification of intra- and extra-cellular signaling pathways that are aberrantly regulated in cancer and are also central to embryonic patterning. The Wnt signaling pathway has provided an outstanding example of this. The genes for β-catenin, APC, and Axin in the Wnt signaling pathway are often mutated in human cancers. In all such cases, the common denominator is the accumulation of cytosolic and nuclear β-catenin and the activation of transcriptional factor Tcf/Lef. The resulting gene expression profile should provide a significant clue as to cancers carrying defects in the Wnt signaling pathway. In this review, the regulation of the β-catenin stability by Axin and APC, and their genetic alterations in human cancers are described.
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| Keywords |
Wnt
β-catenin
APC
Axin
Tcf
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| NDC |
Medical sciences [ 490 ]
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| Language |
eng
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| Resource Type | conference paper |
| Date of Issued | 2006-01-08 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[URI] http://ir.lib.hiroshima-u.ac.jp/meta-bin/mt-pdetail.cgi?smode=1&edm=0&tlang=1&cd=00014842
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