The paper presents a framework for a multi-weather hazard early warning system for application over the Bay of Bengal primarily focusing on Myanmar. The early warning system consists of an observational component based on observations from the Indian Ocean observing System (IndOOS) and a prediction component based on the Regional Environment Simulator (RES). IndOOS consists mainly of an assemblage of Earth observing satellites for key environmental parameters in addition to a complementary in situ observations network. The Regional Environment Simulator (RES) is a coupled system of numerical simulation models for meteorology, physical oceanography, land surface, vegetation, hydrology, coastal dynamics and urban environment. The developed system is supposed to have a major role in predicting, forecasting and issuing of early warnings to reduce the risk in case of extreme weather events in Myanmar.