We compared the hemodynamics of posture change under general anesthesia between prone position and knee chest position. Patients who underwent lumbar spinal surgery were retrospectively investigated. Heart rate (HR) and systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP) were measured before and after postural change, 3 minutes and 5 minutes after postural change. The rate of change of each parameter was calculated and compared in both groups of knee-chest and prone position. Student’s t-test was used as statistical methods. We analyzed 60 patients (30 Knee-chest, 30 Prone). SBP was significantly lower in the Knee-chest group from immediately after postural change to 5 minutes after postural change. MBP was significantly lower in the Knee-chest group 5 minutes after postural change. HR was significantly higher in the Knee-chest group from immediately after body change to 5 minutes after postural change. In conclusion, SBP and MBP were significantly lower in the knee-chest position than in the prone position during postural change. Postural change to the kneechest position requires attention to lowering of blood pressure than postural change to the prone position.