Liposome collapse resulting from an allosteric interaction between 2,6‐dimethyl‐β‐cyclodextrins and lipids
RSC Advances Volume 5 Issue 95
Page 77746-77754
published_at 2015-09-09
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| File | |
| Title ( eng ) |
Liposome collapse resulting from an allosteric interaction between 2,6‐dimethyl‐β‐cyclodextrins and lipids
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| Creator |
Iwata Noboru
Hino Shodai
Mae Tomoya
Tsuchiya Yuki
Ohara Kazuaki
Yamaguchi Kentaro
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| Source Title |
RSC Advances
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| Volume | 5 |
| Issue | 95 |
| Start Page | 77746 |
| End Page | 77754 |
| Abstract |
Although heptakis(2,6‐di‐O‐methyl)‐β‐cyclodextrin (DMe‐β‐CDx) has been reported to exhibit higher cytotoxicity than many other cyclodextrins because of the way in which it abstracts cholesterols from liposomes, we have identified another reason for its cytotoxicity based on its interaction with lipids. These interactions exhibited nonlinear sigmoidal responses with Hill coefficient values (n) in the range of 3.0‒3.6, which indicated that this phenomenon involves positive allosterism. Furthermore, analysis by mass spectroscopy revealed that the lipid•DMe‐β‐CDx complexes had stoichiometric ratios in the range of 1:1‒1:4.
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| Descriptions |
Electronic supplementary information (ESI) available: Average hydrodynamic diameter values and UV-vis absorption, 1H NMR, NOESY and CSI-MS spectra. See DOI: 10.1039/c5ra14970c
This work was supported by a JSPS KAKENHI a Grant‐in‐Aid for Scientific Research (B) (Grant No. 25288037).
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| NDC |
Chemistry [ 430 ]
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| Language |
eng
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| Resource Type | journal article |
| Publisher |
Royal Society of Chemistry
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| Date of Issued | 2015-09-09 |
| Rights |
This journal is © The Royal Society of Chemistry 2015
This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence.
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| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 2046-2069
[DOI] 10.1039/c5ra14970c
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