Antral Somatostatin Contents and Acidity of Gastric Juice in Normal Subjects and Patients with Duodenal Ulcer

SUMII Koji

SUMIOKA Masaaki

HIRATA Ken

UEMURA Naomi

TARI Akira

YOSHIHARA Masaharu

SEKITO Masaki

TOKUTOMI Tadashi

INABA Yoshirou

TESHIMA Hitoshi

INBE Akira

TOKUMO Kenji

OHGOSHI Hiroaki

HARUMA Ken

KAJIYAMA Goro

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

The antral somatostatin contents were investigated in biopsy specimens of the antrum from normal subjects and patients with duodenal ulcer. There was good correlation (r=0.77044) between antral somatostatin contents and maximal acidity in normal subjects, but the correlation between antral somatostatin contents and maximal acid output was not significant (r=0.254367). This result may indicate that antral somatostatin content is regulated by intragastric pH in normal subjects. On the other hands, no correlation was observed between antral somatostatin contents and acidity or acid output in patients with duodenal ulcer.
Therefore the impaired regulation of acid on antral somatostatin contents could be one of the important factors in the pathogenesis of duodenal ulcer disease.

Duodenal Ulcer

Antral somatostatin

Acidity

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 2883159