Detection of chromosome-mediated blaNDM-1-carrying Aeromonas spp. in the intestinal contents of fresh water river fish in Ho Chi Minh City, Vietnam

Yamaguchi Takahiro

Yokota Masaharu

Jinnai Michio

Minh Doan Tran Nguyen

Hoang Oanh Nguyen

Thi Hien Le

Thanh Phong Ngo

Hoai Phuong Hoang

Do Phuc Nguyen

Van Chinh Dang

Motooka Daisuke

Nakamura Shota

Kawahara Ryuji

Kumeda Yuko

Hase Atsushi

Nakayama Tatsuya

Marine Pollution Bulletin

The spread of antibiotic-resistant bacteria is a global problem that should be addressed through the perspective of the “one health” concept. The purpose of this study was to determine the contamination rate of antibiotic-resistant Aeromonas spp. in fresh water river fish purchased from a fish market in Vietnam. We then defined the pattern of antibiotic resistance to assess antibiotic-resistant contamination. Antibiotic-resistant Aeromonas spp. were detected in the intestinal contents of 32 of 80 fish. blaNDM-1 was detected in seven strains. Extended-spectrum β-lactamase and AmpC β-lactamase-related genes were detected in 28 strains, including blaCTX-M-55, blaCTX-M-15, blaCTX-M-1, and blaDHA, blaFOX, and blaMOX. The blaNDM-1 detected in the seven Aeromonas spp. strains were found chromosomally. This finding suggests that the blaNDM gene is stable in the natural environment and may spread widely into animals and humans via Aeromonas spp. with a transposon. Our results suggest the importance of continuing to monitor carbapenemase genes in Aeromonas spp. to evaluate the possibility that they may spread in other Enterobacterales, and to elucidate the mechanism of spread.

Aeromonas spp.

blaNDM-1

Fish

Vietnam

英語

Elsevier

© <2023>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/

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[DOI] https://doi.org/10.1016/j.marpolbul.2023.115812 ～の異版である