Phospholipid Molecular Layer that Enhances Distinction of Odors Based on Artificial Sniffing

Yotsumoto Mai

Matsuo Muneyuki

Kitahata Hiroyuki

Nakanishi Shinobu

Denda Mitsuhiro

Nagayama Masaharu

Nakata Satoshi

ACS Sensors

We propose a novel odor-sensing system based on the dynamic response of phospholipid molecular layers for artificial olfaction. Organisms obtain information about their surroundings based on multidimensional information obtained from sniffing, i.e., periodic perturbations. Semiconductor- and receptor-based odor sensors have been developed previously. However, these sensors predominantly identify odors based on one-dimensional information, which limits the type of odor molecule they can identify. Therefore, the development of odor sensors that mimic the olfactory systems of living organisms is useful to overcome this limitation. In this study, we developed a novel odor-sensing system based on the dynamics of phospholipids that responds delicately to chemical substances at room temperature using multidimensional information obtained from periodic perturbations. Odor molecules are periodically supplied to the phospholipid molecular layer as an input sample. The waveform of the surface tension of the phospholipid molecular layer changes depending on the odor molecules and serves as an output. Such characteristic responses originating from the dynamics of odor molecules on the phospholipid molecular layer can be reproduced numerically. The phospholipid molecular layer amplified the information originating from the odor molecule, and the mechanism was evaluated by using surface pressure–area isotherms. This paper offers a platform for an interface-chemistry-based artificial sniffing system as an active sensor and a novel olfactory mechanism via physicochemical responses of the receptor-independent membranes of the organism.

Sniffing

Surface Tension

Phospholipid Molecular Layer

Odor-Sensing

Dynamic Response

eng

American Chemical Society

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sensors, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssensors.3c00382

This is not the published version. Please cite only the published version.

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[DOI] https://doi.org/10.1021/acssensors.3c00382 isVersionOf

日本学術振興会

Japan Society for the Promotion of Science

[Crossref Funder] https://doi.org/10.13039/501100001691

時空間発展する自己駆動体の構築

Spatiotemporally developed self-propelled objects

20H02712

日本学術振興会

Japan Society for the Promotion of Science

[Crossref Funder] https://doi.org/10.13039/501100001691

自己駆動体の集団運動に対する数理モデリングと数理解析

自己駆動体の集団運動に対する数理モデリングと数理解析

21H00996