Effect of Abdominal Aortic Calcification on Recurrence Following Initial Hepatectomy for Colorectal Liver Metastases

IMAOKA KOUKI

OHIRA MASAHIRO

SHIMOMURA MANABU

HATTORI MINORU

BEKKI TOMOAKI

SATO KOKI

IMAOKA YUKI

AKABANE SHINTARO

NAKANO RYOSUKE

YANO TAKUYA

SAKAI HIROSHI

HIRATA FUMIHIRO

KURODA SHINTARO

TAHARA HIROYUKI

IDE KENTARO

ISHIYAMA KOHEI

KOBAYASHI TSUYOSHI

TANAKA YUKA

OHDAN HIDEKI

Anticancer Research

EISSN 1791-7530

Background/Aim: The aim of the study was to analyze the association between abdominal aortic calcification (AAC) and patient prognosis following resection of colorectal liver metastases (CRLM). AAC potentially reflects intrahepatic immunity and is involved in tumor development and progression. However, the clinical effects of AAC on colorectal cancer (CRC) prognosis after curative-intent liver resection for CRLM remain unclear. Patients and Methods: We evaluated the effect of AAC on the clinical prognosis and metastatic patterns in 99 patients who underwent hepatectomy for CRLM between 2010 and 2019. Results: The high-AAC group had significantly worse overall survival (OS) and remnant liver recurrence rate (RR) after propensity score matching to adjust for differences in baseline characteristics of patients and tumors. In multivariate Cox regression analyses, high AAC volume was an independent risk factor for poor OS and liver RR, but not poor lung RR. The expression of tumor necrosis factor-related apoptosis-inducing ligand, known as an anti-tumor marker, in liver natural killer (NK) cells was lower in the high-AAC group than in the low-AAC group. Conclusion: High AAC volume showed a strong relationship with remnant liver RR after curative resection of CRLM. High AAC volume may be responsible for the suppression of anti-tumor activity of liver NK cells, which results in an increased risk of liver recurrence and poor prognosis.

Aortic calcification

colorectal liver metastasis

tumor necrosis factor-related apoptosis-inducing ligand

propensity score

英語

International Institute of Anticancer Research

© 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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[DOI] https://doi.org/10.21873/anticanres.16854 ～の異版である