Controlling the Magnetic Responsiveness of Cellulose Nanofiber Particles Embedded with Iron Oxide Nanoparticles

Bahri Nur Syakirah Nabilah Saipul

Nguyen Tue Tri

Matsumoto Kohei

Watanabe Mai

Morita Yuko

Eka Lutfi Septiani

Cao Le Anh Kiet

Hirano Tomoyuki

Ogi Takashi

ACS Applied Bio Materials

2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-oxidized cellulose nanofiber (TOCN) particles, an innovative biobased material derived from wood biomass, have garnered significant interest, particularly in the biomedical field, for their distinctive properties as biocompatible particle adsorbents. However, their microscopic size complicates their separation in liquid media, thereby impeding their application in various domains. In this study, superparamagnetic magnetite nanoparticles (NPs), specifically iron oxide Fe3O4 NPs with an average size of 15 nm, were used to enhance the collection efficiency of TOCN-Fe3O4 composite particles synthesized through spray drying. These composite particles exhibited a remarkable ζ-potential (approximately −50 mV), indicating their high stability in water, as well as impressive magnetization properties (up to 47 emu/g), and rapid magnetic responsiveness within 60 s in water (3 wt % Fe3O4 to TOCN, 1 T magnet). Furthermore, the influence of Fe3O4 NP concentrations on the measurement of the speed of magnetic separation was quantitatively discussed. Additionally, the binding affinity of the synthesized particles for proteins was assessed on a streptavidin–biotin binding system, offering crucial insights into their binding capabilities with specific proteins and underscoring their significant potential as functionalized biomedical materials.

TEMPO-Oxidized Cellulose Nanofibers

Iron Oxide Nanoparticles

Nanostructured Material

Spray Drying

Functionalized Composite Particles

Magnetic Separation

Streptavidin-biotin Binding

Biomedical Application

英語

American Chemical Society

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Applied Bio Materials, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acsabm.4c00213

This is not the published version. Please cite only the published version.

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[DOI] https://doi.org/10.1021/acsabm.4c00213 ～の異版である

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