Baseline eosinophil proportion is a useful predictor of immune-related adverse events following immune checkpoint inhibitor treatment for recurrent metastatic head and neck cancer

Hattori Takayoshi

Ueda Tsutomu

Sato Yuki

Chikuie Nobuyuki

Taruya Takayuki

Hamamoto Takao

Hattori Minoru

Ishino Takashi

Takeno Sachio

Acta Oto-Laryngologica

Background
Immune checkpoint inhibitors (ICIs) occasionally cause immune-related adverse events (irAEs) in various organs. However, predictors of irAEs remain unidentified.
Objectives
We evaluated the predictors of irAEs and compared the outcomes of ICIs with and without irAEs in patients with recurrent/metastatic head and neck cancers (R/M HNCs).
Materials and methods
We retrospectively analyzed 157 patients with R/M HNCs who were administered an anti-PD-1 antibody between September 2014 and December 2022. We examined whether various pretreatment factors were associated with irAEs. The overall survival (OS) and progression-free survival (PFS) in patients with and without irAEs were analyzed.
Results
Overall, 44 patients (28.0%) developed irAEs. The survival curve estimated for patients with and without irAEs showed a significant difference in PFS (p = 0.018), but not in OS (p = 0.208). Multivariate analysis revealed significant differences in relative eosinophil counts (p < 0.001), TP (p = 0.014), and NLR (p = 0.002), which may be independent predictors of irAEs.
Conclusion
IrAEs may be associated with higher efficacy of ICIs and longer PFS. The relative eosinophil count may be predictors of irAEs and useful in routine medical practice. Using these biomarkers to predict irAEs will help predict ICI effects and manage irAEs.

背景
免疫检查点抑制剂 (ICI) 偶尔会在各种器官中引起免疫相关不良事件 (irAE)。然而, irAE 的预测因素仍未确定。
目的
我们评估了 irAE 的预测因素, 并比较了有和无 irAE 的复发/转移性头颈癌 (R/M HNC) 患者的ICI 结果。
材料和方法
我们回顾性分析了 2014 年 9 月至 2022 年 12 月期间接受抗 PD-1 抗体治疗的 157 名 R/M HNC 患者。我们检查了各种治疗前因素是否与 irAE 相关。分析了有和无 irAE 的患者的总生存期 (OS) 和无进展生存期 (PFS)。
结果
共有44 名患者 (28.0%) 出现 irAE。有和无 irAE 患者的估计生存曲线显示 PFS 有显著差异(p = 0.018), 但 OS 无显著差异(p = 0.208)。多变量分析显示相对嗜酸性粒细胞计数(p < 0.001)、TP(p = 0.014)和 NLR(p = 0.002)有显著差异, 这些可能是 irAE 的独立预测因子。
结论
免疫相关不良事件可能与 ICI 疗效更高和 PFS 更长相关。相对嗜酸性粒细胞计数可能是 irAE 的预测因子, 在常规医疗实践中很有用。用这些生物标志物来预测 irAE 将有助于ICI 效果的预测及irAE的管理。

Recurrent/metastatic head and neck cancer

immune checkpoint inhibitors

immune-related adverse events

eosinophil

英語

Taylor & Francis

This is an Accepted Manuscript of an article published by Taylor & Francis in Acta Oto-Laryngologica on 20 Sep 2024, available at: https://doi.org/10.1080/00016489.2024.2390084.

This is not the published version. Please cite only the published version.

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[DOI] https://doi.org/10.1080/00016489.2024.2390084 ～の異版である