Cholinergic modulation of interhemispheric inhibition in the mouse motor cortex
Cerebral Cortex 34 巻 7 号
bhae290- 頁
2024-07-23 発行
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ファイル情報(添付) |
利用開始日
2025-07-23
5.4 MB
種類 :
全文
エンバーゴ :
2025-07-23
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タイトル ( eng ) |
Cholinergic modulation of interhemispheric inhibition in the mouse motor cortex
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作成者 |
Zhang Qing
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収録物名 |
Cerebral Cortex
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巻 | 34 |
号 | 7 |
開始ページ | bhae290 |
抄録 |
Interhemispheric inhibition of the homotopic motor cortex is believed to be effective for accurate unilateral motor function. However, the cellular mechanisms underlying interhemispheric inhibition during unilateral motor behavior remain unclear. Furthermore, the impact of the neuromodulator acetylcholine on interhemispheric inhibition and the associated cellular mechanisms are not well understood. To address this knowledge gap, we conducted recordings of neuronal activity from the bilateral motor cortex of mice during the paw-reaching task. Subsequently, we analyzed interhemispheric spike correlation at the cell-pair level, classifying putative cell types to explore the underlying cellular circuitry mechanisms of interhemispheric inhibition. We found a cell-type pair-specific enhancement of the interhemispheric spike correlation when the mice were engaged in the reaching task. We also found that the interhemispheric spike correlation was modulated by pharmacological acetylcholine manipulation. The local field responses to contralateral excitation differed along the cortical depths, and muscarinic receptor antagonism enhanced the inhibitory component of the field response in deep layers. The muscarinic subtype M2 receptor is predominantly expressed in deep cortical neurons, including GABAergic interneurons. These results suggest that GABAergic interneurons expressing muscarinic receptors in deep layers mediate the neuromodulation of interhemispheric inhibition in the homotopic motor cortex.
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著者キーワード |
interhemispheric inhibition
reaching
motor cortex
acetylcholine
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内容記述 |
This work was supported by JSPS KAKENHI 19H0572301, 21H02581, and 23K18256 to H.A., KAKENHI 22K06485 to T.H., and the Program of the Network-type Joint Usage/Research Center for Radiation Disaster Medical Science. A part of this research is based on the Cooperative Research Project of Research Center for Biomedical Engineering.
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言語 |
英語
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資源タイプ | 学術雑誌論文 |
出版者 |
Oxford
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発行日 | 2024-07-23 |
権利情報 |
This is a pre-copyedited, author-produced version of an article accepted for publication in Cerebral Cortex following peer review. The version of record Volume 34, Issue 7, July 2024, bhae290 is available online at: https://doi.org/10.1093/cercor/bhae290.
This is not the published version. Please cite only the published version.
この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
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出版タイプ | Accepted Manuscript(出版雑誌の一論文として受付されたもの。内容とレイアウトは出版社の投稿様式に沿ったもの) |
アクセス権 | エンバーゴ期間中 |
収録物識別子 |
[DOI] https://doi.org/10.1093/cercor/bhae290
~の異版である
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助成機関名 |
日本学術振興会
Japan Society for the Promotion of Science
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助成機関識別子 |
[Crossref Funder] https://doi.org/10.13039/501100001691
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研究課題名 |
うつ病様行動異常における手綱核神経炎症の役割
Inflammatory response of the habenula underlying depressive-like behaviors
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研究課題番号 |
21H02581
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助成機関名 |
日本学術振興会
Japan Society for the Promotion of Science
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助成機関識別子 |
[Crossref Funder] https://doi.org/10.13039/501100001691
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研究課題名 |
脳内ドーパミンの操作による勇敢な行動の誘導
Induction of courageous behavior by modulation of dopamine release in the brain
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研究課題番号 |
23K18256
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助成機関名 |
日本学術振興会
Japan Society for the Promotion of Science
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助成機関識別子 |
[Crossref Funder] https://doi.org/10.13039/501100001691
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研究課題名 |
大脳皮質-線条体経路特異的な光遺伝学的操作による適応行動の神経機序の解明
大脳皮質-線条体経路特異的な光遺伝学的操作による適応行動の神経機序の解明
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研究課題番号 |
22K06485
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備考 | The full-text file will be made open to the public on 23 July 2025 in accordance with publisher's 'Terms and Conditions for Self-Archiving' |