Basic performance assessment of reagents for measuring soluble FMS-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) in Japanese women

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Title ( eng )
Basic performance assessment of reagents for measuring soluble FMS-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) in Japanese women
Creator
NISHIHARA Haruna
YAMAZAKI Shinichi
ARASE Takashi
Source Title
Hiroshima Journal of Medical Sciences
Volume 71
Issue 3-4
Start Page 51
End Page 55
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Among the factors associated with angiogenesis, soluble FMS-like tyrosine kinase-1 (sFlt-1) is antiangiogenic and placental growth factor (PlGF) is proangiogenic. The sFlt-1/PlGF ratio is considered useful for the short-term prediction of preeclampsia (PE) in high-risk pregnancies and has been used clinically in Japan since July 2021. Regarding the clinical use of the sFlt-1/PlGF ratio in Japan, there have been no published reports demonstrating that sFlt-1 and PlGF assay reagents have the same basic performance in Japanese and European women. To our knowledge, we conducted the first basic performance assessment of the sFlt-1 and PlGF assay reagents using sera from Japanese women. We obtained satisfactory results for repeatability, intermediate precision, linearity, effects of interferents, and the LoQ. The sFlt-1 and PlGF assay reagents performed well, and we believe that they are entirely adequate for use in routine clinical assays of Japanese patients, similar to those in European patients.
Keywords
sFlt-1
PlGF
hypertensive disorders of pregnancy
preeclampsia
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2022-12
Rights
Copyright (c) 2022 Hiroshima University Medical Press
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312