Differences in the electric potential of pancreatic head cancer tissues
Hiroshima Journal of Medical Sciences Volume 71 Issue 1-2
Page 23-30
published_at 2022-06
アクセス数 : 368 件
ダウンロード数 : 177 件
今月のアクセス数 : 6 件
今月のダウンロード数 : 1 件
この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00052901
File |
HiroshimaJMedSci_71_23.pdf
4.16 MB
種類 :
fulltext
|
Title ( eng ) |
Differences in the electric potential of pancreatic head cancer tissues
|
Creator |
ISHIGAME Souichi
URABE Kazuhide
MORI Keiichi
|
Source Title |
Hiroshima Journal of Medical Sciences
|
Volume | 71 |
Issue | 1-2 |
Start Page | 23 |
End Page | 30 |
Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
Abstract |
Identifying the electrical properties of cancer relies on the understanding of the electric potential (EP) of cancer tissues. This study aimed to investigate the EP properties in 49 pancreatic head cancer tissues using a digital multimetre. The anode was placed at the central side of the tumour, and the electric potential differences (EPDs) between cancerous and cancerous, cancerous and noncancerous, and noncancerous and noncancerous lesions at approximately 1-cm intervals following resection were evaluated. Pathological evaluation identified 30 of these samples as pancreatic invasive ductal carcinoma (PIDC, 10 without preoperative chemotherapy and 20 after chemotherapy), seven other pancreatic cancers, three tumours of Vater’s ampulla (VA), and eight extrahepatic cholangiocarcinoma (EHCC) samples. We also evaluated the differences in pH for cancerous and noncancerous lesions in nine PIDC samples. Our data suggest that the EP of pancreatic cancerous tissues is higher than that of noncancerous tissues, especially in PIDCs. We also noted that EPD was the highest when comparing cancerous and noncancerous lesions. Additionally, PIDC tissues presented with low pH; the pH difference between cancerous and noncancerous sites was significantly correlated with EPD (P = 0.011). These EPDs were also correlated with tumour size in PIDCs and inversely correlated with their response to chemotherapy. The EP values for both the cancerous and noncancerous sites in both the VA tumours and EHCC samples were not significantly different, whereas EPD in PIDC correlated with tumour extension and viable tumour content, suggesting that EPD might be useful for evaluating the viability and effectiveness of neoadjuvant chemotherapy.
|
Keywords |
Electrical Potential
Pancreatic Cancer
pH
Chemotherapy
Warburg Effect
|
Descriptions |
This research was partially supported by a Grant-in-Aid for Scientific Research (A) (Nos. 15H02567 and 17H05102) from the Ministry of Education, Culture, Sports, Science, and Technology, and the Ministry of Health, Labour, and Welfare for Japan.
|
Language |
eng
|
Resource Type | departmental bulletin paper |
Publisher |
Hiroshima University Medical Press
|
Date of Issued | 2022-06 |
Rights |
Copyright (c) 2022 Hiroshima University Medical Press
|
Publish Type | Version of Record |
Access Rights | open access |
Source Identifier |
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312
[DOI] 10.24811/hjms.71.1-2_23
|