Sudden Hearing Loss in a Young Patient with Chronic Myelogenous Leukemia

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Title ( eng )
Sudden Hearing Loss in a Young Patient with Chronic Myelogenous Leukemia
Creator
CHISHAKI Ren
ISHIKAWA Chie
EDAHIRO Taro
MINO Tatsuji
Source Title
Hiroshima Journal of Medical Sciences
Volume 70
Issue 2-4
Start Page 39
End Page 42
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
Hyperleukocytosis is a typical presentation of chronic myelogenous leukemia (CML). It sometimes induces leukostasis, the symptoms of which include visual change, headache, tinnitus, dizziness, and occasional disturbance of consciousness. In the present study, a 26-year-old male patient visited a general physician, who observed marked hyperleukocytosis and referred the patient to our hospital. The patient was diagnosed with CML and treated with a tyrosine kinase inhibitor and hydroxycarbamide. On the fourth day after admission, the patient suddenly complained of left-sided hearing loss. An audiogram revealed profound left sensorineural hearing loss. Magnetic resonance imaging of the head showed no lesions in the inner ear, cerebellum, or brain stem; therefore, we diagnosed sudden hearing loss due to leukostasis. Subsequently, his hearing did not improve, despite a decrease in leukocytes. The pathophysiology of leukocytosis involves increased leukocytes and thrombi, which induce high blood viscosity in the microcirculation. Leukostasis-related infarction and hemorrhage can lead to occlusion of the labyrinthine artery, causing deafness. Physicians should be aware that deafness can develop when diagnosing marked leukocytosis because such deafness is irreversible in most cases.
Keywords
Chronic myelogenous leukemia
Hyperleukocytosis
Sudden hearing loss
Adolescents and young adults
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 2021-12
Rights
Copyright (c) 2021 Hiroshima University Medical Press
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[ISSN] 2433-7668
[NCID] AA00664312
[DOI] 10.24811/hjms.70.2-4_39
[DOI] https://doi.org/10.24811/hjms.70.2-4_39