Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes
Neuroscience Research 154 巻
9-19 頁
2020-05 発行
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この文献の参照には次のURLをご利用ください : https://ir.lib.hiroshima-u.ac.jp/00051067
| ファイル情報(添付) | |
| タイトル ( eng ) |
Serotonergic modulation of feeding behavior in Caenorhabditis elegans and other related nematodes
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| 作成者 |
Ishita Yuuki
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| 収録物名 |
Neuroscience Research
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| 巻 | 154 |
| 開始ページ | 9 |
| 終了ページ | 19 |
| 抄録 |
Serotonin is a conserved neuromodulator that controls feeding behavior in response to environmental inputs in a wide range of species, including the nematode, Caenorhabditis elegans. To understand the detailed mechanism and evolution of serotonergic neuromodulation, the feeding behaviors of C. elegans and related species have been studied intensively because of their simple neural anatomy and genetic manipulability. C. elegans shows patterned movements of a feeding structure called the pharynx, and serotonin modulates feeding rhythms via several serotonin receptors expressed in pharyngeal motor neurons and muscles. Environmental inputs and physiological states like food signals, starvation, and heat affect the activity of serotonergic neurons and downstream neural pathways. We focus on serotonergic neural pathways in the feeding behavior of C. elegans and other nematodes, neuromodulation between environmental inputs and behavioral outputs, and their evolutionary path.
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| 著者キーワード |
tph-1
Serotonin receptor
Pharyngeal movement
Pharyngeal pumping
Peristalsis
Environmental inputs
Pristionchus pacificus
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| 内容記述 |
This work was supported by JSPS KAKENHI Grant Number 18K14716 to M.O. and 18H05369 to T.C. This work is also supported by the Sumitomo foundation, Grant for Basic Science Research Projects to M. O., and Toray Science Foundation and The Frontier Development Program for Genome Editing to T.C.
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier
Japan Neuroscience Society
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| 発行日 | 2020-05 |
| 権利情報 |
© 2020. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認、ご利用ください。
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 0168-0102
[DOI] 10.1016/j.neures.2019.04.006
[PMID] 31028772
[DOI] https://doi.org/10.1016/j.neures.2019.04.006
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