Newly Synthesized Compound, PABA-Ursodeoxycholic Acid, for Evaluation of Intestinal Bacteria

アクセス数 : 360
ダウンロード数 : 61

今月のアクセス数 : 1
今月のダウンロード数 : 0
File
HiroshimaJMedSci_36_377.pdf 650 KB 種類 : fulltext
Title ( eng )
Newly Synthesized Compound, PABA-Ursodeoxycholic Acid, for Evaluation of Intestinal Bacteria
Creator
TAKAHASHI Makoto
MAEDA Yorinobu
MATSUNO Kiyoshi
TAMURA Hiroyuki
FURUYASHIKI Susumu
HARADA Mitsuo
Source Title
Hiroshima Journal of Medical Sciences
Volume 36
Issue 4
Start Page 377
End Page 381
Journal Identifire
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
Abstract
From the standpoint of utilizing a distinctive feature of para-aminobenzoic acid (PABA) and intestinal bile acid metabolism, a conjugate of ursodeoxycholic acid with PABA (PABA-UDCA) was newly synthesized for studying whether it can be a good material or not to evaluate enteric bacteria. In incubation experiment, this compound was reasonably deconjugated by cholylglycine hydrolase resulting in the release of PABA. In animal experiment, urinary excretions of PABA were determined during six hours following oral administration of 10 mg PABA-UDCA. Control rats (n=7) excreted 140.1 ± 59.5 μ,g (mean ± SD) of PABA. By contrast, the rats (n=9) with intestinal antisepsis by antibiotic administration excreted less (18.3 ± 16. 7 μg; P < 0.001) whereas those with intestinal bacterial overgrowth by making enteric blind loop excreted more (451.1 ± 223.6 μg; P < 0.01). These observations indicate that this new compound is likely to offer a simple and rapid method for evaluation of the intestinal microorganisms.
Keywords
Bile acids and salts
Bacteria
Intestinal diseases
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type departmental bulletin paper
Publisher
Hiroshima University Medical Press
Date of Issued 1987-12
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3502343