Experimental Evaluation of Bretschneider's Solution for Myocardial Preservation in Cardiac Transplantation

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タイトル ( eng )
Experimental Evaluation of Bretschneider's Solution for Myocardial Preservation in Cardiac Transplantation
作成者
SUEDA Taijiro
MAEDA Yoshiyuki
HAMANAKA Yoshiharu
ISHIHARA Hiroshi
MATSUURA Yuichiro
KAJIHARA Hiroki
収録物名
Hiroshima Journal of Medical Sciences
36
3
開始ページ 309
終了ページ 313
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
Myocardial preservation by Bretschneider's solution (BR solution, Group I) with an intracellular like electrolyte and histidine buffer action was compared with EC-Bi solution (Group II) which has an extracellular like electrolyte and bicarbonate buffer action in the mongrel dogs. The PH and PCO2 of the effluent from the coronary sinus were maintained during myocardial ischemia for 3 hr but the lactate rose gradually in group I. The oxygen and lactate up-take ratio of the myocardium after re-perfusion was satisfactory and LV max dp/dt was also maintained at a high level in group I. Morphologically, myelin figure and mitochondrial deformation were more found in group II on electron microscopy.
A donor heart preserved for 3 hr in cold BR solution was transplanted in the left thoracic cavity in four mongrel dogs by the technique of the heterotopic cardiac transplantation. Resuscitation of cardiac pulsation was smooth and maintenance of the systemic circulation after transplantation was possible in every case. From these findings, it might be concluded that myocardial preservation using cold BR solution was useful for cardiac transplantation.
著者キーワード
Myocardial protection
Cardiac transplantation
Bretschneider's solution
Heterotopic cardiac transplantation
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 1987-09
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3121539