Liver Injury Following Long-Term Administration of Large Doses of Sake to Rats

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タイトル ( eng )
Liver Injury Following Long-Term Administration of Large Doses of Sake to Rats
作成者
WATANABE Akiharu
NAKATSUKASA Harushige
KOBAYASHI Michio
NAGASHIMA Hideo
収録物名
Hiroshima Journal of Medical Sciences
36
3
開始ページ 277
終了ページ 281
収録物識別子
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
抄録
The hepatotoxic effect on rats of long-term (55 weeks) administration of sake (a rice wine, 17% ethanol by volume) at large doses (average 12.6 g ethanol/kg body weight/day) was investigated in order to gain an insight into the reasons for the high incidence of liver fibrosis in Japanese alcoholics. Rats grew favorably under the experimental conditions, and daily variations in blood ethanol and acetaldehyde levels ranged from 3.8 to 21.1 mM and from O to 3.5 μM, respectively. Fatty and fibrotic liver was shown histologically and biochemically in sake-administered rats.
著者キーワード
Sake
Alcohol
Liver injury
Fatty and fibrotic liver
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 紀要論文
出版者
Hiroshima University Medical Press
発行日 1987-09
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3692892