Liver Injury Following Long-Term Administration of Large Doses of Sake to Rats
Hiroshima Journal of Medical Sciences Volume 36 Issue 3
Page 277-281
published_at 1987-09
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| File | |
| Title ( eng ) |
Liver Injury Following Long-Term Administration of Large Doses of Sake to Rats
|
| Creator |
WATANABE Akiharu
NAKATSUKASA Harushige
KOBAYASHI Michio
NAGASHIMA Hideo
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 36 |
| Issue | 3 |
| Start Page | 277 |
| End Page | 281 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
The hepatotoxic effect on rats of long-term (55 weeks) administration of sake (a rice wine, 17% ethanol by volume) at large doses (average 12.6 g ethanol/kg body weight/day) was investigated in order to gain an insight into the reasons for the high incidence of liver fibrosis in Japanese alcoholics. Rats grew favorably under the experimental conditions, and daily variations in blood ethanol and acetaldehyde levels ranged from 3.8 to 21.1 mM and from O to 3.5 μM, respectively. Fatty and fibrotic liver was shown histologically and biochemically in sake-administered rats.
|
| Keywords |
Sake
Alcohol
Liver injury
Fatty and fibrotic liver
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University Medical Press
|
| Date of Issued | 1987-09 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3692892
|
