Urinary Excretion of Inorganic and Organic Fluoride after Inhalation of Sevoflurane
Hiroshima Journal of Medical Sciences Volume 36 Issue 1
Page 99-104
published_at 1987-03
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| File | |
| Title ( eng ) |
Urinary Excretion of Inorganic and Organic Fluoride after Inhalation of Sevoflurane
|
| Creator |
DAVIDKOVA Tatiana Ivanova
FUJII Kohyu
KIKUCHI Hirosato
HORIBE Mayumi
MUKAIDA Keiko
SATO Nobuyoshi
MORIO Michio
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 36 |
| Issue | 1 |
| Start Page | 99 |
| End Page | 104 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
This study was designed to investigate the defluorination of sevoflurane in patients. Five patients, scheduled for orthopedic surgery, were administered sevoflurane for 60 min during NLA-nitrous oxide-oxygen. The end-tidal concentration of sevoflurane was adjusted at 0.6% throughout the entire inhalation period.
The serum concentration of inorganic F- increased significantly 15 min after the onset of inhalation and reached a plateau at 45 min with a mean value about 15 μM. The serum organic fluoride level increased significantly 45 min after the onset of inhalation and did not change significantly 4 hr later with a mean value of about 140 μM. The elimination half-lives and rate constants were calculated from urinary data to be 2040 min and 0.00034 for inorganic fluoride and 1800 min and 0.00038 for organic fluoride respectively. The ratio organic/inorganic fluoride was calculated to be 2.3. |
| Keywords |
Anesthetics
volatile: sevoflurane
Biotransformation: fluorometabolites
Pharmacokinetics: excretion
Toxicity: metabolites
|
| Descriptions |
This study was supported in part by a Grant-in-aid for Science Research from the Ministry of Education, Science and Culture of Japan.
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1987-03 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3583810
|
