Penicillin Resistance of Pseudomonas aeruginosa Clinical Isolates from Urinary Tract Infections
Hiroshima Journal of Medical Sciences Volume 35 Issue 4
Page 355-362
published_at 1986-12
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| File | |
| Title ( eng ) |
Penicillin Resistance of Pseudomonas aeruginosa Clinical Isolates from Urinary Tract Infections
|
| Creator |
SANDA Noriaki
NAKANO Hiroshi
MIYAKE Yoichiro
SUGINAKA Hidekazu
NIHIRA Hiromi
|
| Source Title |
Hiroshima Journal of Medical Sciences
|
| Volume | 35 |
| Issue | 4 |
| Start Page | 355 |
| End Page | 362 |
| Journal Identifire |
[PISSN] 0018-2052
[EISSN] 2433-7668
[NCID] AA00664312
|
| Abstract |
One hundred and thirteen clinical isolates of Pseudomonas aeruginosa from urinary tract infections were tested for their mechanisms of resistance to penicillins. Ninety-eight percent and 100.0% of the strains were resistant (MIC≧100 μg/ml) to ampicillin and penicillin G, respectively, while only 5.3% were resistant to piperacillin. Low permeability of the outer membrane, and penicillinase production were involved in their resistance mechanisms. Peptidoglycan synthesis in ether-treated cells of two representative strains was inhibited by ampicillin and piperacillin at the concentrations markedly lower than that for penicillin G.
|
| Keywords |
Penicillin
Antibiotic resistance
Urinary tract infection
Pseudomonas aeruginosa
|
| NDC |
Medical sciences [ 490 ]
|
| Language |
eng
|
| Resource Type | departmental bulletin paper |
| Publisher |
Hiroshima University School of Medicine
|
| Date of Issued | 1986-12 |
| Publish Type | Version of Record |
| Access Rights | open access |
| Source Identifier |
[ISSN] 0018-2052
[NCID] AA00664312
[PMID] 3106269
|
