Familial Aggregation of Duodenal Ulcer and an Autosomal Dominant Inheritance of Hyperpepsinogenemia I

SUMII Koji

UEMURA Naomi

INBE Akira

HARUMA Ken

INABA Yoshiro

TARI Akira

YOSHIHARA Masaharu

SEKITOH Masaki

TOKUTOMI Tadashi

KAJIYAMA Goro

MIYOSHI Akima

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

To clarify genetic factors involved in the familial aggregation of duodenal ulcer, serum pepsinogen I levels were determined by radioimmunoassay in patients with duodenal ulcer and their affected and unaffected relatives.
There existed relationship between an elevated pepsinogen I level and susceptability of duodenal ulcer, and the familial aggregation of duodenal ulcer. The segregation analysis revealed that hyperpepsinogenemia I was inherited as an autosomal dominant inheritance, and in some families this trait was responsible for familial aggregation of duodenal ulcer. But in other families normopepsinogenemic I duodenal ulcer has segregated and association to pathophysiological factors of this trait was obscure. These data provide evidence that genetic factors play a role in pathogenesis of duodenal ulcer, and that hyperpepsinogenemia I is one of genetic markers of this disease.

Duodenal ulcer

Hyperpepsinogenemia I

Autosomal dominant inheritance

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 3771276