Chromosome Abnormalities in 1355 Induced Abortuses

OHAMA Koso

KUSUMI Ichiro

FUJIWARA Atsushi

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

A total of 1536 induced abortuses of less than 12 weeks gestation were cultured and 1355 successfully karyotyped. The study was divided into two periods: in the initial period 1224 abortion specimens were randomly collected, but in the later period 312 specimens of less than 8 weeks gestation or from women over 35 years of age were selectively collected. Eighty-six or 6.3% of the 1355 karyotyped specimens had chromosome abnormalities, and these included 61 trisomics, 9 monosomy X, 7 triploids, 5 double aneuploids, 2 tetraploids, one balanced translocation and one mosaic trisomy 22. Chromosomal abnormality rates by five-year maternal age intervals were 3.4 to 3.6% for women under 34 years of age, 9.3% for women aged 35-39 years and 23.0% for women over 40 years. Factors that may influence the prevalence of abnormal karyotypes in induced abortuses and prenatal selection rates of chromosome abnormalities compatible with livebirth are discussed.

Induced abortus

Chromosome abnormality

Prenatal selection rate

Maternal age effect

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 3771271