Clinical Effect of Infusion Therapy in Combination with Local Antimycotic Drugs on Acute Pseudomembraneous Candidiasis Induced by Removable Dentures

KOMAI Tadashi

HAMADA Takeshi

HAMADA Taizo

TAMAMOTO Mitsuhiro

SHIGETO Naofumi

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

Denture stomatitis is often observed in the denture-bearing mucosa. Candida albicans and related species are now believed to play a major role as a pathogenic factor in denture stomatitis. If systemic predisposing factors are present, denture stomatitis will sometimes develop into acute pseudomembraneous candidiasis. In acute pseudomembraneous candidiasis, the patients cannot take foods, and dehydration often occurs. This vicious cycle is the most important cause of increase in the growth of Candida species. Therefore, in order to improve the patient's physical condition, infusion therapy will be the first choice of treatment. The purpose of this study was to investigate the clinical effect of infusion therapy in combination with local antimycotic drugs on this type of candidiasis.
We observed 4 cases of acute pseudomembraneous candidiasis induced by removable dentures and tried to treat these patients with infusion therapy (5% dextrose in lactatedRinger's solution) and local antimycotic drugs (Nystatin ointment or 1 % Miconazole nitrate cream). The acute inflammatory symptoms were significantly decreased by this therapy.
The result of this study indicated that infusion therapy in combination with local antimycotic drugs was clinicaly effective on acute pseudomembraneous candidiasis induced by Candida-induced denture stomatitis.

Oral candidiasis

Candida albicans

Denture stomatitis

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 3744880