The Influence of Truncal Vagotomy on Acute Gastric Mucosal Lesion in Obstructive Jaundice

KODAMA Osamu

TAKEUCHI Hitoshi

ITO Nobuaki

TANAKA Tsuneo

SEIKOH Rokuro

ICHIBA Yasuyuki

DOHI Kiyohiko

Hiroshima Journal of Medical Sciences

[PISSN] 0018-2052

[EISSN] 2433-7668

[NCID] AA00664312

With a view to examining the influence of truncal vagotomy on acute gastric mucosal lesion (AGML) in obstructive jaundice, the authors prepared the non-vagotomized group and the vagotomized group of rats with obstructive jaundice. Further, cold restraint stress was loaded on the two groups for 30 min, and the following results were obtained:
1) The incidence of AGML in the vagotomized group before stress was inhibited to 17% in both the 3-week group and 4-week group, as compared to 33-38% in the non-vagotomized group. The incidence of AGML in the vagotomized group after stress was inhibited to 17% in the 3-week group and 33% in the 4-week group, as compared to 78% in the non-vagotomized group.
2) Gastric mucosal histamine (HA) contents in the vagotomized group before stress in both the 3-week group and the 4-week group were significantly increased (p < 0.05) as compared with the levels in the non-vagotomized group. As concerns gastric mucosal serotonin (5-HT) contents, however, no significant difference was noted between both groups. The contents of both amines in the gastric mucosa in the non-vagotomized group, a significant decrease (p < 0.05) was observed in both the 3-week group and 4-week group after stress, while in the vagotomized group no significant changes were found.

Obstructive jaundice

AGML

Truncal vagotomy

Amine

Medical sciences [ 490 ]

eng

Hiroshima University School of Medicine

[ISSN] 0018-2052

[NCID] AA00664312

[PMID] 4066401