Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis
International Journal of Molecular Medicine 22 巻 3 号
381-387 頁
2008-09 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis
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| 作成者 |
Kayashima Tomoko
Mori Masaharu
Yoshida Hiromi
Mizushina Yoshiyuki
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| 収録物名 |
International Journal of Molecular Medicine
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| 巻 | 22 |
| 号 | 3 |
| 開始ページ | 381 |
| 終了ページ | 387 |
| 抄録 |
Vitamins play essential roles in cellular reactions and maintain human health. Recent studies have revealed that some vitamins including D3, B6 and K2 and their derivatives have an anti-cancer effect. As a mechanism, their inhibitory effect on cancer-related angiogenesis has been demonstrated. Vitamin K2 (menaquinones) has an anti-cancer effect in particular for hepatic cancer and inhibits angiogenesis. In the current study, we demonstrated that sole vitamin K3 (menadione) selectively inhibits the in vitro activity of eukaryotic DNA polymerase γ, which is a mitochondrial DNA polymerase, and suppresses angiogenesis in a rat aortic ring model. The anti-angiogenic effect of vitamin K3 has been shown in angiogenesis models using human umbilical vein endothelial cells (HUVECs) with regard to HUVEC growth, tube formation on reconstituted basement membrane and chemotaxis. These results suggest that vitamin K3 may be a potential anti-cancer agent like vitamin K2.
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| 著者キーワード |
angiogenesis
aortic ring
endothelial cells
vitamin K3
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| 内容記述 |
This work was supported by the ‘Academic Frontier’ Project for Private Universities (Kobe-Gakuin University), matching fund subsidy from MEXT, 2006-2010, (K.M., H.Y. and Y.M.) and in part by a grant from the Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT). K.M. acknowledges a Grant-in-Aid for Young Scientists (B) (No. 18700608) from MEXT. Y.M. also acknowledges a Grant-in-Aid for Young Scientists (A) (No. 19680031) from MEXT, and Grants-in-Aid from the Nakashima Foundation and the Foundation of Oil & Fat Industry, Kaikan, Japan.
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Spandidos Publications
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| 発行日 | 2008-09 |
| 権利情報 |
Copyright (c) 2008 Spandidos Publications UK Ltd.
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
Matsubara, K., Kayashima, T., Mori, M., Yoshida, H., Mizushina, Y. "Inhibitory effects of vitamin K3 on DNA polymerase and angiogenesis". International Journal of Molecular Medicine 22, no. 3 (2008): 381-387.
[ISSN] 1107-3756
[ISSN] 1791-244X
[DOI] 10.3892/ijmm_00000034
[PMID] 18698499
[DOI] https://doi.org/10.3892/ijmm_00000034
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