Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from 𝛽-Lactoglobulin Secreted by Lactococcus lactis
BioMed Research International 2014 巻
393598- 頁
2014-08-03 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Generation of Dipeptidyl Peptidase-IV-Inhibiting Peptides from 𝛽-Lactoglobulin Secreted by Lactococcus lactis
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| 作成者 |
Shigemori Suguru
Oshiro Kazushi
Wang Pengfei
Wang Yeqin
Sato Takashi
Uyeno Yutaka
Shimosato Takeshi
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| 収録物名 |
BioMed Research International
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| 巻 | 2014 |
| 開始ページ | 393598 |
| 抄録 |
Previous studies showed that hydrolysates of 𝛽-lactoglobulin (BLG) prepared using gastrointestinal proteases strongly inhibit dipeptidyl peptidase-IV (DPP-IV) activity in vitro. In this study, we developed a BLG-secreting Lactococcus lactis strain as a delivery vehicle and in situ expression system. Interestingly, trypsin-digested recombinant BLG from L. lactis inhibited DPP-IV activity, suggesting that BLG-secreting L. lactis may be useful in the treatment of type 2 diabetes mellitus.
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| 内容記述 |
The study was supported by a grant from the Iijima Memorial Foundation for the Promotion of Food Science and Technology to Takeshi Shimosato.
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Hindawi Publishing Corporation
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| 発行日 | 2014-08-03 |
| 権利情報 |
Copyright © 2014 Suguru Shigemori et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 2314-6133
[ISSN] 2314-6141
[DOI] 10.1155/2014/393598
[PMID] 25157356
[DOI] http://dx.doi.org/10.1155/2014/393598
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