The Pharmacokinetics of Low-Dose Thalidomide in Japanese Patients with Refractory Multiple Myeloma

Biological and Pharmaceutical Bulletin 29 巻 11 号 2331-2334 頁 2006-11 発行
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タイトル ( eng )
The Pharmacokinetics of Low-Dose Thalidomide in Japanese Patients with Refractory Multiple Myeloma
作成者
Kamikawa Rintaro
Asaoku Hideki
Iwato Koji
Sasaki Ayako
収録物名
Biological and Pharmaceutical Bulletin
29
11
開始ページ 2331
終了ページ 2334
抄録
Thalidomide has been used for the treatment of refractory multiple myeloma, the dosage in Japan is lower than in other countries; however, there is little information on the pharmacokinetics and their relationship with the drug response. The aim of this study was to characterize the pharmacokinetics of low-dose thalidomide in Japanese patients with refractory multiple myeloma, and to examine the relationship between pharmacokinetics and adverse events. On the first and second days, a 100 mg capsule was administered to 8 Japanese patients after breakfast and blood samples were obtained. The plasma concentrations were measured using HPLC and analyzed based on a one-compartment model. If intolerable adverse events were not observed for 14 d, the dose was increased to 200 mg. The average apparent volume of distribution (Vd/F), apparent total clearance (CL/F) and area under the plasma concentration–time curve from 0 to infinity (AUC0—∞), which were 45.3 l, 5.5 l/h and 21.7 μg·h/ml, respectively, with smaller Vd/F and CL/F and larger AUC0—∞ than in Caucasian populations. This pharmacokinetic difference may explain the dose difference between Japan and other countries. Adverse events were associated with AUC0—∞, which was best correlated with plasma concentration at 12 h after administration. The 12-h time point was suggested to be a capable indicator for “safety-oriented” therapeutic drug monitoring of thalidomide.
著者キーワード
thalidomide
pharmacokinetics
multiple myeloma
NDC分類
医学 [ 490 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
The Pharmaceutical Society of Japan
発行日 2006-11
権利情報
© 2006 Pharmaceutical Society of Japan
出版タイプ Version of Record(出版社版。早期公開を含む)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 0918-6158
[ISSN] 1347-5215
[NCID] AA10885497
[DOI] 10.1248/bpb.29.2331
[DOI] https://doi.org/10.1248/bpb.29.2331