Flow cytometry-based diagnosis of primary immunodeficiency diseases
Allergology International 67 巻 1 号
43-54 頁
2018-01 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Flow cytometry-based diagnosis of primary immunodeficiency diseases
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| 作成者 |
Kanegane Hirokazu
Hoshino Akihiro
Okano Tsubasa
Yasumi Takahiro
Wada Taizo
Takada Hidotoshi
Yamashita Motoi
Yeh Tzu-wen
Nishikomori Ryuta
Takagi Masatoshi
Imai Kohsuke
Ochs Hans D.
Morio Tomohiro
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| 収録物名 |
Allergology International
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| 巻 | 67 |
| 号 | 1 |
| 開始ページ | 43 |
| 終了ページ | 54 |
| 抄録 |
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited diseases of the immune system. The definite diagnosis of PID is ascertained by genetic analysis; however, this takes time and is costly. Flow cytometry provides a rapid and highly sensitive tool for diagnosis of PIDs.
Flow cytometry can evaluate specific cell populations and subpopulations, cell surface, intracellular and intranuclear proteins, biologic effects associated with specific immune defects, and certain functional immune characteristics, each being useful for the diagnosis and evaluation of PIDs. Flow cytometry effectively identifies major forms of PIDs, including severe combined immunodeficiency, X-linked agammaglobulinemia, hyper IgM syndromes, Wiskott-Aldrich syndrome, X-linked lymphoproliferative syndrome, familial hemophagocytic lymphohistiocytosis, autoimmune lymphoproliferative syndrome, IPEX syndrome, CTLA 4 haploinsufficiency and LRBA deficiency, IRAK4 and MyD88 deficiencies, Mendelian susceptibility to mycobacterial disease, chronic mucocuneous candidiasis, and chronic granulomatous disease. While genetic analysis is the definitive approach to establish specific diagnoses of PIDs, flow cytometry provides a tool to effectively evaluate patients with PIDs at relatively low cost. |
| 著者キーワード |
Flow cytometry
Intracellular protein
Monoclonal antibody
Primary immunodeficiency disease
Surface protein
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| 内容記述 |
This study was supported by grants from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Ministry of Health, Labour, and Welfare of Japan.
Supplementary data related to this article can be found at http://dx.doi.org/10.1016/j.alit.2017.06.003
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| NDC分類 |
医学 [ 490 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Japanese Society of Allergology
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| 発行日 | 2018-01 |
| 権利情報 |
Copyright © 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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| 出版タイプ | Version of Record（出版社版。早期公開を含む） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 1323-8930
[DOI] 10.1016/j.alit.2017.06.003
[PMID] 28684198
[DOI] https://doi.org/10.1016/j.alit.2017.06.003
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