Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy

Allergology International Volume 64 Issue 4 Page 312-320 published_at 2015-10
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Title ( eng )
Spectrum of allergens for Japanese cedar pollinosis and impact of component-resolved diagnosis on allergen-specific immunotherapy
Creator
Source Title
Allergology International
Volume 64
Issue 4
Start Page 312
End Page 320
Abstract
The high prevalence of Japanese cedar pollinosis in Japan is associated with a negative impact on the quality of life of patients, as well as significant loss of productivity among the workforce in early spring, thus representing a serious social problem. Furthermore, the prevalence is increasing, and has risen by more than 10% in this decade. Cry j 1 and Cry j 2 were identified as the major allergens in Japanese cedar pollen (JCP), and in 2004, the existence of other major and minor allergens were revealed by a combination of two- dimensional electrophoresis and immunoblotting analysis. Allergenome analysis identified a chitinase, a lipid transfer protein, a serine protease, and an aspartic protease as novel IgE-reactive allergens in patients with JCP allergy. Thaumatin-like protein (Cry j 3) was shown to be homologous to Jun a 3, a major allergen from mountain cedar pollen. Isoflavone reductase-like protein was also characterized in a study of a JCP cDNA library. The characterization of component allergens is required to clarify the sensitizer or cross-reactive elicitor allergens for component-resolved diagnosis (CRD). Increasing evidence from numerous clinical trials indicates that CRD can be used to design effective allergen-specific immunotherapy. In this review, we summarize the eight characterized JCP allergens and discuss the impact of CRD and characterization of novel allergens on allergen-specific immunotherapy.
Keywords
Allergen-specific immunotherapy
Component-resolved diagnosis
Japanese cedar pollinosis
Oral allergy syndrome
Seasonal rhinitis
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
Japanese Society of Allergology
Date of Issued 2015-10
Rights
Copyright © 2015, Japanese Society of Allergology. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 1323-8930
[DOI] 10.1016/j.alit.2015.05.008
[PMID] 26433527
[DOI] https://doi.org/10.1016/j.alit.2015.05.008