PREPARATION OF OPTICALLY ACTIVE 2,2-DISUBSTITUTED 5-HYDROXYCHROMENES BY ENZYMATIC RESOLUTION OF RACEMIC ESTERS

Heterocycles Volume 97 Issue 1 Page 604-611 published_at 2018-05-18
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Title ( eng )
PREPARATION OF OPTICALLY ACTIVE 2,2-DISUBSTITUTED 5-HYDROXYCHROMENES BY ENZYMATIC RESOLUTION OF RACEMIC ESTERS
Creator
Kainuma Mika
Yamada Ai
Katakawa Kazuaki
Source Title
Heterocycles
Volume 97
Issue 1
Start Page 604
End Page 611
Abstract
Enzymatic kinetic resolution of racemic esters of 2,2-disubstituted 5-hydroxychromenes was examined. Transesterification of acetate using Amano Lipase PS in the presence of t-BuOH was most effective to give the corresponding optically active acetate in 18% yield and 95% ee. The absolute configuration of the acetate was determined as R based on the conversion to teretifolione B with natural absolute configuration.
NDC
Medical sciences [ 490 ]
Language
eng
Resource Type journal article
Publisher
The Japan Institute of Heterocyclic Chemistry
Date of Issued 2018-05-18
Rights
Copyright (c) 2018 The Japan Institute of Heterocyclic Chemistry
Publish Type Version of Record
Access Rights open access
Source Identifier
[ISSN] 0385-5414
[ISSN] 1881-0942
[DOI] 10.3987/COM-18-S(T)45