Formation of lipid membrane‐incorporated small π‐molecules bearing hydrophilic groups

RSC Advances 6 巻 82 号 78505-78513 頁 2016-08-12 発行
アクセス数 : 736
ダウンロード数 : 186

今月のアクセス数 : 1
今月のダウンロード数 : 1
ファイル情報(添付)
RSCAd_6-82_78505.pdf 706 KB 種類 : 全文
タイトル ( eng )
Formation of lipid membrane‐incorporated small π‐molecules bearing hydrophilic groups
作成者
Ashizawa Kengo
Tsuchiya Yuki
収録物名
RSC Advances
6
82
開始ページ 78505
終了ページ 78513
抄録
Nineteen poorly water‐soluble π‐conjugated molecules were evaluated in terms of their ability to be stably incorporated into lipid membranes. The resulting lipid membrane-incorporated π‐conjugated guest molecules (LMIGs) were classified into four categories, including (i) those that formed stable LMIGs; (ii) those where some of guest molecules precipitated; (iii) those that formed small self‐aggregates consisting of lipids and/or guest molecules; and (iv) those that leaked some of the guest molecules into the bulk water. Compounds belonging to category (ii) were confirmed by UV‐vis absorption analysis. In contrast, compounds belonging to categories (i), (iii) and (iv) were discriminated based on their 1H NMR spectra and the broadening or disappearance of the peaks of the guest molecules and the lipids in LMIGs and large liposomes. Several LMIGs could be converted from one category to another using other lipids. Furthermore, the guest molecules belonging to category (iv) were successfully predicted using the octanol‐water partition coefficient, which was calculated by simulation.
内容記述
This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI Grant‐in‐Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant‐in‐Aid for Challenging Exploratory Research (Grant No. JP16K13982).
NDC分類
化学 [ 430 ]
言語
英語
資源タイプ 学術雑誌論文
出版者
Royal Society of Chemistry
発行日 2016-08-12
権利情報
This journal is © The Royal Society of Chemistry 2016
This is the accepted manuscript of an article is available at http://dx.doi.org/10.1039/C6RA18635A.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
出版タイプ Author’s Original(十分な品質であるとして、著者から正式な査読に提出される版)
アクセス権 オープンアクセス
収録物識別子
[ISSN] 2046-2069
[DOI] 10.1039/C6RA18635A