Control of the incorporation and release of guest molecules by photodimerization in liposomes
Journal of Photochemistry and Photobiology B: Biology 185 巻
235-240 頁
2018-08 発行
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| ファイル情報(添付) | |
| タイトル ( eng ) |
Control of the incorporation and release of guest molecules by photodimerization in liposomes
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| 作成者 |
Shimokawa Ryo
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| 収録物名 |
Journal of Photochemistry and Photobiology B: Biology
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| 巻 | 185 |
| 開始ページ | 235 |
| 終了ページ | 240 |
| 抄録 |
In a drug-delivery system using liposomes, the use of guest molecules bearing hydrophilic moieties results in some leakage from lipid membranes. We suppressed the leakage of coumarins (used as model guest molecules in a drug-delivery system) from lipid membranes by photodimerization at 365 nm. The reason for this phenomenon could be ascribed to an increase in the hydrophobicity of the dimers of the coumarins. The formation of the dimers was detected by 1H NMR, UV-vis absorption, and mass spectra and the leakage percentages of the coumarins were determined by 1H NMR spectra based on the peak intensities. In contrast, when the dimer reverted to a monomer by ultraviolet (254 nm) irradiation, the resulting monomer was released from liposomes.
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| 著者キーワード |
Liposomes
Drug delivery
Photochemistry
Host-guest system
Dimerization
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| 内容記述 |
This work was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
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| NDC分類 |
化学 [ 430 ]
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| 言語 |
英語
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| 資源タイプ | 学術雑誌論文 |
| 出版者 |
Elsevier B.V.
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| 発行日 | 2018-08 |
| 権利情報 |
Copyright (c) 2018 Elsevier B.V.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license. http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認ご利用ください。
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| 出版タイプ | Author’s Original（十分な品質であるとして、著者から正式な査読に提出される版） |
| アクセス権 | オープンアクセス |
| 収録物識別子 |
[ISSN] 1011-1344
[DOI] 10.1016/j.jphotobiol.2018.06.008
[PMID] 29966990
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| 備考 | Post-print version/PDF may be used in an institutional repository after an embargo period of 24 months. |
