Control of the incorporation and release of guest molecules by photodimerization in liposomes

Journal of Photochemistry and Photobiology B: Biology Volume 185 Page 235-240 published_at 2018-08
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Title ( eng )
Control of the incorporation and release of guest molecules by photodimerization in liposomes
Creator
Shimokawa Ryo
Source Title
Journal of Photochemistry and Photobiology B: Biology
Volume 185
Start Page 235
End Page 240
Abstract
In a drug-delivery system using liposomes, the use of guest molecules bearing hydrophilic moieties results in some leakage from lipid membranes. We suppressed the leakage of coumarins (used as model guest molecules in a drug-delivery system) from lipid membranes by photodimerization at 365 nm. The reason for this phenomenon could be ascribed to an increase in the hydrophobicity of the dimers of the coumarins. The formation of the dimers was detected by 1H NMR, UV-vis absorption, and mass spectra and the leakage percentages of the coumarins were determined by 1H NMR spectra based on the peak intensities. In contrast, when the dimer reverted to a monomer by ultraviolet (254 nm) irradiation, the resulting monomer was released from liposomes.
Keywords
Liposomes
Drug delivery
Photochemistry
Host-guest system
Dimerization
Descriptions
This work was supported by a JSPS KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
NDC
Chemistry [ 430 ]
Language
eng
Resource Type journal article
Publisher
Elsevier B.V.
Date of Issued 2018-08
Rights
Copyright (c) 2018 Elsevier B.V.
This manuscript version is made available under the CC-BY-NC-ND 4.0 license. http://creativecommons.org/licenses/by-nc-nd/4.0/
This is not the published version. Please cite only the published version. この論文は出版社版ではありません。引用の際には出版社版をご確認ご利用ください。
Publish Type Author’s Original
Access Rights open access
Source Identifier
[ISSN] 1011-1344
[DOI] 10.1016/j.jphotobiol.2018.06.008
[PMID] 29966990
Remark Post-print version/PDF may be used in an institutional repository after an embargo period of 24 months.