Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes

Organic and Biomolecular Chemistry Volume 15 Issue 8 Page 1786-1791 published_at 2017-02-28

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Title ( eng )	Incorporation of large guest molecules into liposomes via chemical reactions in lipid membranes
Creator	Tsuchiya Yuki Sugikawa Kouta Ueda Masafumi Ikeda Atsushi
Source Title	Organic and Biomolecular Chemistry
Volume	15
Issue	8
Start Page	1786
End Page	1791
Abstract	The incorporation of hydrophobic guest molecules into lipid membranes by the exchange of the guest molecule from a cyclodextrin (CDx) complex to a liposome is limited to guest molecules that can be included in CDxs. To solve this problem, large guest molecules were incorporated into liposomes by chemical reactions of guest molecules in lipid membranes. Stable lipid-membrane-incorporated fullerene derivatives with large substituent(s) were prepared by Diels–Alder reactions in lipid membranes.
Descriptions	Electronic supplementary information (ESI) available: Schematic representation of the premixing and exchange methods, 1H NMR spectra and UV-vis absorption spectra. See DOI: 10.1039/c6ob02343f This work was supported by the Japanese Society for the Promotion of Science (JSPS) KAKENHI Grant-in-Aid for Scientific Research (B) (Grant No. JP16H04133) and a Grant-in-Aid for Challenging Exploratory Research (Grant No. JP16K13982).
NDC	Chemistry [ 430 ]
Language	eng
Resource Type	journal article
Publisher	Royal Society of Chemistry
Date of Issued	2017-02-28
Rights	Copyright (c) 2017 The Royal Society of Chemistry This is an open access article distributed under the terms of the Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
Publish Type	Version of Record
Access Rights	open access
Source Identifier	[ISSN] 1477-0520 [DOI] 10.1039/c6ob02343f [PMID] 27918054